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KMID : 0861019980130020057
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Korea Journal of Herbology
1998 Volume.13 No. 2 p.57 ~ p.68
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A study on the Antiallergic Effect of Cortex Betula Platyphyllae or Cortex Pruni Serrulatae Extract
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朴殷秀/Park, Eun-Soo
辛民敎/宋昊埈/Shin, Min-Kyo/Song, Ho-Joon
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Abstract
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Anti-allergic effects resulted by Cortex Betula Platyphyllae(CB) or Cortex Pruni Serrulatae(CP) extract were observed from the mast cell before or after treatment with Compound 48/80, anti-DNP IgE and Substance P, respectively. In addition, it was investigated on inhibition of IgE release from B cell line and spleen cell after treatment with two extracts.
The results were as follows ;
1. CB or CP extract inhibited Anaphylaxis shock induced by intraperitoneal injection with Compound 48/80.
2. Both extracts inhibited histamine release from the mast cell after treatment with Compound 48/80, anti-DNP IgE or Substance P.
3. The IgE release stimulated from spleen cell of mouse after treatment with LPS or LPS plus IL-4 was inhibited with increasing concentrations of extracts. The level of IgE release was significantly much lower in treatment of CB extract than that of CP extract when compared to high concentrations of extracts.
4. The IgE release from U266B1 of human myeloma was inhibited dependently to the concentrations of CB and CP extract, respectively, and CB extract inhibited effectively more IgE release than that after treatment of CP extract.
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KEYWORD
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